The trailer indicates a very Uncharted-looking bunch of people running from some very 28 Days Later(-meets-demonic-broccoli) looking infected. Color us excited. The Last of Us is due exclusively for the PlayStation 3 in 2012.
Update: The press release is out, linked at the Source link below, and the official site is up at www.lastofus.com. There's not much in the way of information, but the presser does note that "The Last of Us is developed by some of the industry's most talented game designers including Bruce Straley, game director, and Neil Druckmann, creative director." The plot description goes something like this: "Abandoned cities are being reclaimed by nature and the remaining survivors are killing each other for food, weapons and whatever they can get their hands on. Joel, a ruthless survivor, and Ellie, a brave young teenage girl who is wise beyond her years, must work together to survive their journey across what remains of the United States."